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https://doi.org/10.15255/KUI.2020.023
Published: Kem. Ind. 69 (13) (2020) P11–P20
Paper reference number: KUI-23/2020
Paper type: Original scientific paper
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Release Rate Enhancement of Lurasidone Hydrochloride from Orally Disintegrating Tablets using Lyophilisation

J. Skočibušić, J. Barbarić and K. Žižek

Abstract

This paper investigates the possibilities for release rate enhancement of lurasidone hydrochloride, a second-generation antipsychotic, by preparing solid dispersions via lyophilisation process. FTIR, DSC, and XRPD measurements have been performed in order to detect potential interactions between lurasidone hydrochloride and polymer matrices that might significantly increase drug solubility and provide faster release from the dosage form. Such solid dispersions and excipients have been used in the preparation of tablets that disintegrate in less than 3 min. In vitro dissolution profiles indicate a higher drug release rate from disintegrating tablets in comparison to pure LRS HCl.


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Keywords

lurasidone hydrochloride, amorphous solid dispersion, lyophilisation, orally disintegrating tablet, drug release