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https://doi.org/10.15255/KUI.2019.035
Published: Kem. Ind. 68 (9-10) (2019) 427–436
Paper reference number: KUI-35/2019
Paper type: Review
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Application of Mathematical Modelling in Development of Enzymatic Cascade Reactions

N. Milčić, M. Česnik, M. Sudar and Z. Findrik Blažević

Abstract

Today, systems biocatalysis, i.e., the implementation of cascade reactions that mimic cellular metabolic pathways, is increasingly being used. Cascade reactions have numerous advantages over traditional chemical processes; however, in order to successfully optimize and transfer such complex systems to a larger, industrial scale, it is necessary to apply reaction engineering. This review paper provides examples of the successful application of mathematical modelling in development of enzymatic cascade reactions that demonstrate the importance and potential of this methodology.


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Keywords

reaction engineering, biocatalysis, modelling, optimisation, multi-enzymatic systems