https://doi.org/10.15255/KUI.2015.050
Published: Kem. Ind. 65 (11-12) (2016) 595–604
Paper reference number: KUI-50/2015
Paper type: Review
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3-Hydroxypyridin-4-ones (Part I): Preparation and Chelation Ability

Ž. Car, V. Petrović Peroković and S. Tomić Pisarović

Abstract

Since the discovery of deferiprone in 1982, so far the only 3-hydroxypyridin-4-one chelator for hard metal ions that is clinically approved, these heterocyclic derivatives have become an intensively studied group of compounds. This review presents the two most common synthetic methods used for the preparation of the heterocyclic 3-hydroxypyridin-4-one structure, the Harris method and the direct procedure, as well as the most important physical and chemical parameters needed for the preliminary evaluation of their chelating abilities.

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Keywords

3-hydroxypyridin-4-ones, direct synthesis, Harris method, iron(III), chelating agent, physical and chemical properties